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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 14 Documents
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Search results for , issue "JKKI, Vol 12, No 2, (2021)" : 14 Documents clear
Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review Daffara Kinanthi Lustikaiswi; Sapto Yuliani; Rahmah Annura; Elmi Rahmadani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art11

Abstract

As the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tryptophan acts as a precursor to serotonin and kynurenine. The serotonin metabolite, 5-hydroxyindoleacetate or 5-hydroxyindoleacetic acid (5-HIAA), can degrade amyloid-ß (Aß) oligomers, a peptide group of 36–43 amino acids derived from amyloid precursor protein found in people with Alzheimer's disease. The degradation of brain cells through the increase of neprilysin (NEP) and melatonin inhibits glycogen synthase kinase-3ß (GSK3ß) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?ß) by reducing the decrease in peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). Meanwhile, in the kynurenine pathway, kynurenic acid (KYNA) also induces the NEP gene, thus preventing Aß.
The decrease of histomorphometry and function of pancreas in male albino rats after induced by sleep deprivation Fitranto Arjadi; Nur Signa Aini Gumilas; Ika Murti Harini; Pugud Samodro; Andromeda Andromeda
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art3

Abstract

Background: Sleep disturbance accelerates type 2 diabetes mellitus by reducing insulin secretion and by the occurrence of difficulty in controlling sleep behaviour in humans so that it is necessary conduct a study by using experimental animals.Objective: This study aims to determine histophotometric differences of pancreas and differences of glucose tolerance in male albino rats (Rattus norvegicus) after induced by stress paradoxical sleep deprivation (PSD) and total sleep deprivation (TSD). Methods: This study applied a post-test only with control groups consisting of 30 male albino rats (Wistar strain) divided randomly into 3 groups: control group, PSD group and TSD group. The mean number and diameter of islets of Langerhans were calculated per slide and were averaged for each group at a magnification of 400 X. The percentage of beta cells in one islet of Langerhans was (ß-p) that was a number of normal beta cells (Bn) divided for the total beta cells (Bt) (normal and damaged) x 100%. The glucose level based on the sampling time was made a curve shape, and the area under the 0-to-120-minute curves (AUC0-120) was calculated by using a trapezoidal formula.Results: The lowest AUC0-120 level of glucose was the control group (14,082 ± 955mg/dL) and the highest was the TSD group (16,293 ± 2,195 mg/dL); the Post-Hoc LSD test showed a significant difference (p<0.05) between the control-PSD group and the TSD-control group. The mean result of pancreatic ß cells mass with the lowest number was in the TSD group (76.3 ± 4.8), and the highest result was in the control group (94.3 ± 2.7); Post-Hoc LSD showed a significant difference (p <0.05) in the control-PSD group and the TSD-control group. The lowest mean in cell diameter of islets of Langerhans was in the TSD group (0.132 ± 0.031 mm), and the highest mean was in the control group (0.213 ± 0.019 mm). Conclusion: Sleep deprivation could reduce pancreatic ß cell mass and cell diameter of islets of Langerhans and increase glucose tolerance levels.
Prevention of noise induced hearing loss in worker: A literature review Febri Endra Budi Setyawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art12

Abstract

Noise induced hearing loss (NIHL) is a hearing loss due to noise that exceeds the hearing threshold limit value (TLV) in a work environment. Impacts of this disorder are decreased concentration, fatigue, headaches, sleep disturbances, and loss of job. Therefore, it is very important for industry stakeholders and workers to understand about the NIHL, so they can prevent and rehabilitate  this problem. Risk factors that affect degrees of severity of deafness are noise intensity, frequency, duration of exposure per day, length of work, individual sensitivity, age and other factors that can cause deafness. Based on this, it can be understood that an amount of received exposure of noise energy will be similarly proportional as obtained damage. In general, NIHL cannot be cured but can be prevented and rehabilitated. Its prevention can be by applying hearing conservation program (HCP) such as noise measurement procedure, noise control, periodic audiometry measurement, hearing protection, worker education, recording, and evaluation. Some of benefits that can be obtained from the hearing conservation program are as a guide to diagnose hearing loss to prevent health impacts from noise exposure.
Effect of antiretroviral therapy to liver function of people living with HIV/AIDS patients in West Papua Mirna Widiyanti; Setyo Adiningsih; Evi Iriani Natalia; Dedi Ananta Purba
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art4

Abstract

Background : Antiretroviral (ARV) therapy is one of the efforts to combat HIV/AIDS in Indonesia, especially West Papua. One of the side effects using ARV is impaired liver function in People Living with HIV/AIDS (PLWHA). ARV therapy evaluation to liver disorders can be seen from the Serum Glutamic Oxaloacetic Transaminase (SGOT)/ Serum Glutamic Pyruvic Transaminase (SGPT) level.Objective : To find out the effect of ARV Fixed Dosed Combination (FDC) to liver function of PLWHA patients in West Papua.Methods : A cross-sectional study, involving 110 respondents who were PLWHA patients receiving ARV at Voluntary Counselling and Testing (VCT) service of hospital in Manokwari, Sorong, and Fak-fak. Laboratory tests was used to examine the liver function. Other variable data were obtained from medical records. The Fisher Exact Test with a significance level of <0.05 was used to determine the effect of ARV to liver function.Results : Respondents had no liver problems with normal SGOT and SGPT values, i.e. 72,7% and 76.4%, respectively. While, the rest had mild and moderate toxicity. Respondent experiencing moderate toxicity was 2 patients who regularly took FDC in Sorong.Conclussion : The FDC using in ARV therapy did not significantly influence the increase of SGOT and SGPT on PLWHA patients in West Papua.
Phenomena of bullying behaviour on adolescents in boarding school Ema Waliyanti; Fauziah Anggitha Swesty
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art5

Abstract

Background: A large number of bullying cases occurred on adolescents in boarding schools can impact on physical and psychological conditions that make them inconvenient in their schools and boarding schools. Boarding schools are more prone of bullying incidents than public schools because their students interact each other more often, either in their schools or dorms. Objective: This study aims to observe bullying behaviour of adolescents in a boarding school in Yogyakarta.Methods: This study was a qualitative method with a phenomenological approach. Its data collection technique was conducted by interviewing. There were 11 participants in this study consisting of eight adolescents and three boarding school teachers who were determined by a purposive sampling. To validating its data, this study used a source triangulation, peer debriefing, and thick description. Then, its data analysis applied the Open Code 4.03. Results: This study showed that bullying behaviour occurred in the boarding school were physical bullying, verbal bullying and relational bullying. Factors that contributed for the bullying behaviour were physical forms, social intercourses of adolescent, emotional attitudes, histories of bullying, seniority, and bullying punishment that are applied ineffectively. Responding to the bullying incidents, the boarding school made policies by making rules about bullying, intervening by advice, applying school punishment, and initiating preventative effortsConclusion: Bullying behaviour of the adolescent occurred in the boarding school includes physical bullying, verbal bullying, and relational bullying that requires attention from all parties, including schools. Schools are expected to provide socialization related to the bullying and to cooperate with all school members to prevent repetitive incidents of bullying.
Outcome benefits to transurethral resection of the prostate in patients with benign prostatic hyperplasia at Medan regional hospital Richman Patandung; Syah Mirsya Warli
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art6

Abstract

Background: Benign prostatic hyperplasia (BPH) is a pathologic process that cause of lower urinary tract symptoms (LUTS) in aging men. Transurethral resection of the prostate (TURP) is still the current gold standard of BPH treatment. International Prostate Symptoms Score (IPSS) and the quality of life (QoL) index are used for assessing the TURP results.Objective: This study would like to show the benefits outcome of TURP in patients with BPH evaluated with IPSS score and QoL index in Medan regional hospital.Methods: This research is a retrospective study of BPH patients that is treated with TURP at Universitas Sumatera Utara Hospital from September 2019 – August 2020. Patients will be divided into 2 groups, group 1 with patients who have a prostate size <80 grams and the second group with a prostate size> 80 grams. All patients who were included in this study were assessed for their complaints using the IPSS and QoL index before and after taking an operation. Statistical analysis was performed using independent t test and Mann Whitney test. The data were significant if the p value < 0.05. Results: There are 60 patients enrolled in this study that treated with TURP. The mean age of patients in the group 1 was 69.57 ± 7.698 years and 69.84 ± 5.893 years in the group 2. There is no significant difference between group 1 and group 2 in postoperative IPSS and QoL results (p >0.05). Conclusion: TURP procedure is preferable option of BPH for patients in any prostate size.
Association between screen time and dry eye symptoms Janeth Angelica Jansen; Cisca Kuswidyati; Febie Chriestya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art7

Abstract

Background: Electronic media has become a necessity in everyday life because of its function to access information, communication, etc. These functions cause an increase in average screen time and risk of developing dry eye symptoms such as photophobia, grittiness, sore eyes, and blurred vision.Objective: This study aims to determine whether there is a relationship between screen time and dry eye symptoms.Methods: An observational-analytic study with a cross-sectional approach was conducted on 66 medical students. All students would download a screen time application on each electronic media they have for one week before data collection. Furthermore, data were collected using a questionnaire consisted of screen time and Ocular Surface Disease Index (OSDI) and were statistically analyzed.Results: A total of 90.91% of the students use electronic media =8 hours/day. The proportion of students who experience dry eye symptoms is 46.97%. There was no statistically significant between screen time and dry eye symptoms (p = 0.676).Conclusion: More than ninety percent of students spend more than 8 hours/day using electronic media but no statistically significant between screen time and dry eye (p>0.05).
Antimicrobial compound from Trichoderma harzianum, an endophytic fungus associated with ginger (Zingiber officinale) Harwoko Harwoko; Jungho Lee; Georgios Daletos; Michael Feldbrügge; Rainer Kalscheuer; Peter Proksch
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art8

Abstract

Background: Genus Trichoderma of fungal kingdom are largely used as biological control agents due to broad-spectrum activity against plant pathogens.Objective: This study aimed to investigate Trichoderma harzianum, an endophytic fungus obtained from ginger (Zingiber officinale) leaves.Methods: The chemical structures of the isolated compounds were deduced on the basis of UV, 1H NMR and MS data analyses, as well as comparison with literature.Results: Two known tetramic acid derivatives were isolated from this fungus, including harzianic acid (A) and isoharzianic acid (B). Compound B inhibited the growth of a corn pathogenic fungus, Ustilago maydis, with inhibition zone diameter (39 ± 0.33 mm) larger than nystatin (29 mm). Additionally, iso-HA (B) revealed antibacterial effect towards Staphylococcus aureus with MIC value of 25 µM. However, both compounds showed no cytotoxicity against human cervical and ovarian cancer cell lines.Conclusion: T. harzianum produced antimicrobial compound like iso-HA which has potential application either in agricultural or health.
The use of hyperuricemia herbs at “Hortus Medicus” herbal medicine clinic Tawangmangu Danang Ardiyanto; Agus Triyono; Ulfatun Nisa; Ulfa Fitriani; Peristiwan RW Astana; Fajar Novianto; Zuraida Zulkarnain
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art9

Abstract

Background: Hyperuricemia has become a health problems in Indonesia lately. The use of traditional medicine, especially herbs, has been used in the treatment of hyperuricemia. Hortus Medicus Herbal Medicine Clinic Tawangmangu has several herbal formulas that are applied in the care of hyperuricemia patients.Objective: This study aims to determine the description of the mostly used medicinal plants for hyperuricemia and the percentage of efficacy of hyperuricemia therapy using medicinal plant. Methods: This study was a retrospective cross-sectional study using purposive sampling. The total sample was 120 medical records and prescriptions for hyperuricemia patients at Hortus Medicus clinic for the period July-December 2020. Results: There were 3 hyperuricemia herbs formulas used in Hortus Medicus. Based on the calculation of the doctor's prescription for hyperuricemia, the first herbal formula consisting of secang (Caesalpinia sappan) bark, tempuyung (Sonchus arvensis) herb, kepel (Stelechocarpus burahol) leaf was prescribed as many as 72 prescriptions (60%). The second herbal formula consisting of cabe jawa (Piper retrofactum), daun sendok (Plantago mayor) leaves, celery (Apium graveolens) herbs with 36 prescriptions (30%), and the third herbal formula consisting of rumput bolong (Equisetum debille) herb, temulawak (Curcuma xanthorizza), turmeric (Curcuma domestica) with 12 prescriptions (10%). The therapeutic efficacy of herbal formula 1st, 2nd and 3rd were 80%; 60%; 50%. There was no significant relationship between sex and the outcome of hyperuricemia therapy (p= 0.804).Conclusion: Among three hyperuricemia herbal formulas used in Hortus Medicus, the 1st formula was mostly used. The percentage of therapeutic efficacy was also higher compared to the other two formulas. 
Chronic kidney dissease and complex urinary tract infection in children with left renal agenesis : A case report Maria Ulfa; Tunjung Wibowo; Desy Rusmawatiningtyas; Kristia Hermawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art13

Abstract

Child with left renal agenesis fulfill the diagnostic criteria for chronic kidney disease due to its structural abnormalities that lasted for more than three months. It is important to monitored the disease progression and also growth, development and quality of life in children with chronic disease. Management of other risk factors that can accelerate disease progression must be carried out comprehensively. The patient's was 9 months old girl with stage I chronic kidney disease and also having recurrent complex urinary tract infections with left renal agenesis. The interventions was  to identify other abnormalities of the urinary tract and syndromic disorders, prevention of urinary tract infection (UTI) recurrence, prevention of renal injury, renal scaring and dietary education. After 18 months of observation there was no urinary tract abnormality in imaging results, there was one episode of mild  recurrent UTI, no renal injury and there was no sign of renal scaring. The final outcome was no significant decrease in glomerular filtration rate (GFR), growth and development was good and good quality of life. The immunizations was given as scheduled. Monitoring and multidisciplinary intervention of prognostic variables such as urinary tract and syndromic disorders, recurrence UTI, renal injury, renal scaring and diet in children with chronic kidney disease are important for optimal outcome. No decrease of GFR, good growth, development and optimal quality of life and also knowing the progression of  chronic kidney disease was the final outcomes of the intervention.

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